a)
Interpretation:
How to carry out the transformation shown is to be stated.
Concept introduction:
The double bonds in the side chain can be reduced without affecting those in the
To state:
How to carry out the transformation shown.
b)
Interpretation:
How to carry out the transformation shown is to be stated.
Concept introduction:
The carboxylic acid or ester or the carbonyl group in
To state:
How to carry out the transformation shown.
c)
Interpretation:
How to carry out the transformation shown is to be stated.
Concept introduction:
The carboxylic acid or ester or the carbonyl group in aldehydes and ketones can be reduced without affecting the double bonds in the side chain and in the aromatic ring using LiAlH4 in ether. The alcohol can be converted in to a bromide by treating with PBr3. The bromo compound when treated with NaSH will yield the thiol required,
To state:
How to carry out the transformation shown.
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Chapter 17 Solutions
Organic Chemistry
- What reagents should be used to carry out the following syntheses?arrow_forwardElectrophilic aromatic substitution usually occurs at the 1-position of naphthalene, also called the a position. Predict themajor products of the reactions of naphthalene with the following reagents. cyclohexanol and BF3arrow_forwardPropose the synthesis for the following transformations.arrow_forward
- What is the major substitution product for the following reaction? Show the mechanism for the reaction.arrow_forwardHow would you carry out the following transformations. Indicate the appropriete reagents in each case.arrow_forwardA step in a synthesis of PGE1 (prostanglandin E1, alprostadil) is reaction of a trisubstituted cyclohexene with bromine to form a bromolactone. Alprostadil is used as temporary therapy for infants born with congenital heart defects that restrict pulmonary blood flow. It brings about dilation of the ductus arteriosus, which in turn increases blood flow in the lungs and blood oxygenation. Propose a mechanism for formation of This bromolactone, and account for the observed stereochemistry of each substituent on the cyclohexane ring.arrow_forward