Q: How
A: Introduction :- Genetic testing also known as DNA testing, involves obtaining DNA from a sample of…
Q: What is the difference between saying that cancer is inherited and saying that the predisposition to…
A: A hereditary inclination or hereditary weakness to malignant growth implies that an individual has…
Q: During a routine check-up, a woman is informed by her doctor that she has developed a skin tumor.…
A: *Benign tumors stay in their location without invading other sites of the body. *They do not spread…
Q: Having a mutant form of the gene XYZ is associated with a higher incidence of cancer than is seen in…
A: A mutant gene XYZ is linked with higher incidences of causing cancer than other mutation. The XYZ…
Q: Should genetic testing for cancer be availablefor everyone, or should genetic testingbe confined to…
A: Cancer is an abnormal proliferation of body cells that has undergone mutation. The cancer is of…
Q: What are genetic markers? Why are they important?
A: Genetic markers are a gene with the known location on the chromosomes. Example: Minisatellite and…
Q: Why is it only the risk for cancer that is inherited?
A: ANSWER --Introduction -- Genes are part of the chromosomes , carry instructions to make proteins…
Q: What are the most significant environmental agents that contributeto human cancers?
A: Cancer is the disease of uncontrolled cell division.
Q: In cancer like disease, what kind of mutations are more focussed? Single Nucleotide Polymorphism or…
A: Introduction Cancer is well known disease now a day. In US, 1 in 2 women and 1 in 3 men develops…
Q: Which genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 gene and is…
A: P53 is the tumor suppressor protein (TP53 in humans) which is also described as the guardian of the…
Q: How much of an impact do environmental factors (such as changes in lifestyle) have on Progeria…
A: Diseases caused by the the damaged or mutated LMNa gene that codes for lamin protein. This protein…
Q: what advantage is there to having one copy of the sickle cell gene and one copy of the normal gene
A: Sickle cell anemia is a genetic disorder in which there is a mutation in the hemoglobin gene. The…
Q: How do translocations such as the Philadelphia chromosome contribute to cancer?
A: Translocations generate novel chromosomes, a segment from one chromosome is transferred to a…
Q: A subset of colorectal cancers is associated with mutations in the Mut genes which code for proteins…
A: There are some Mut enzymes that check the identity of newly formed DNA and if there are certain…
Q: Most forms of cancer are caused by environmental agents that produce mutations in somatic cells. Is…
A: Environmental factors have been known to trigger a lot of the mutations which develop into cancerous…
Q: Regarding albinism, with adavances in fields such as gene therapy and stem cell research, is there a…
A: Introduction :- Albinism is an inherited condition in which the rate of melanin production is…
Q: In Cystic Fibrosis: How is the gene/chromosome affected? How is the cell, tissue, and body systems…
A: Cystic fibrosis is an innate sickness that influences the lungs and stomach related framework. The…
Q: How would you relate the cancer cellular pathophysiology with genomic instability?
A: Introduction Cancer is well known disease now a day. In US, 1 in 2 women and 1 in 3 men develops…
Q: What is loss of heterozygosity and how does this process contribute to the development of cancers?
A: Genetics is a part of science worried about the investigation of genes, genetic variation, and…
Q: Why is chromosome 15 absence affects?
A: Absence of a segment chromosome is type of chromosomal aberration known as deletion. Deletion…
Q: Are genome and karyotype instabilities consequencesor causes of cancer?
A: Genome ad karyotype instabilities really leads to cancer.Lets have a detailed discussion: Genome…
Q: How do normal cells protect themselves from accumulating mutations in genes that could lead to…
A: Studies reveal that the p53 protein instructs cells to under-go apoptosis when mutations in the DNA…
Q: How do oncogenes differ from tumor suppressor genes?
A: Oncogenes are a physically and functionally diverse set of genes, the protein products of which act…
Q: What is 18th chromosome abnormality?
A: The chromosomes are the thread like structure that contains hereditary information in the form of…
Q: What is FISH? Briefly describe how it works How is FISH used to characterize chromosomal…
A: FISH ( fluorescence in situ hybridization ) is a technique for detecting and locating a specific DNA…
Q: What is chromosome 15 abnormality?
A: Chromosomes are long thread-like structures that carry coded genetic information in the form of DNA.…
Q: How cancer is genetic diseases, in spite of the fact that most cancers are not inherited?
A: Cancer is a disease that involves the uncontrollable growth of some of the abnormal cells of the…
Q: Describe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote…
A: It codes for a protein or a functional product rRNA (ribosomal RNA) or tRNA (transfer RNA). DNA is…
Q: Many people with mutated alleles that are associated with diseases, including some cancers, do not…
A: A rapid change in the sequence of DNA (deoxyribonucleic acid) due to physical or chemical factors is…
Q: How can two cells with the same genes become different cell types?
A: A cell is the basic key of life that is capable of performing all the functions of life and also…
Q: Patients with XP suffer extremely high incidence of skin cancer but have not been found to have…
A: There are 2 basic types of genetic mutations: Acquired mutations. These are the most common causes…
Q: What is the significance of the Philadelphia chromosome, and how is it related to leukemia?
A: Chromosomes are the structures present in the nucleus that appear thread like and contain genes.…
Q: How does the normal p53 protein inhibit cancer development?
A: Tumor-suppressor genes code for proteins that repair damaged DNA (preventing a cell from turning…
Q: Why are oncogenes usually dominant in their action, whereas tumor-suppressor genes are recessive?
A: BASIC INFORMATION ONCOGENES When there is alteration in the proto-onco genes then it leads to the…
Q: How do we know that malignant tumors arise from a single cell that contains mutations?
A: Malignant tumors are multicellular cell masses invading normal tissues and disrupting their function…
Q: In cell growth, how does the normal allele of BRCA1 work? Is it an oncogene or a tumor suppressor…
A: Cell growth is a very complex and orderly process in which various enzymes cell signaling pathways…
Q: How do BRCA1 and BRCA2 function in regard to cell proliferation (are they proto-oncogenes,…
A: jjBRCA proteins play an important role in a variety of biological functions. In response to DNA…
Q: Most inherited forms of cancer show a dominant pattern of inheritance in a pedigree. An example is a…
A: BRCA-1 gene is associated with breast cancer which is located on the chromosome-17. This gene was…
Q: What is haploinsufficiency? How might it affect cancer risk?
A: The term in genetics that explains the function of the dominant gene in the representation of…
Q: Which are the Genetic Basis of Cancers?
A: Cancer is a disease related to abnormal growth of cells where the cells have the potential to spread…
Q: Is it correct to say that the palladin gene causes cancer?
A: This palladin gene encodes a cytoskeletal protein that is required for organizing the actin…
Q: How is cancer different from most other types of genetic diseases?
A: Cancer is the abnormal growth and multiplication of normal cells. Cancer cell divide rapidly. Cancer…
Q: how can mutations in several genes drive cancer?
A: Ans: Mutation: The change in the nucleotide sequence base level (single base) is referred to as…
Q: can you explain how most cancers are not inherited, but are genetic
A: Cancer is the uncontrolled growth of abnormal cells in our body. Cancerous cells have the property…
Why is the Philadelphia chromosome important to understanding & treating some cancers, especially CML?
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- A small fraction—2 to 3%—of all cancers, acrossmany subtypes, displays a quite remarkable phenome-non: tens to hundreds of rearrangements that primarilyinvolve a single chromosome, or chromosomal region.The breakpoints can be tightly clustered, with several in afew kilobases; the junctions of the rearrangements ofteninvolve segments of DNA that were not originally closetogether on the chromosome. The copy number of varioussegments within the rearranged chromosome was foundto be either zero, indicating deletion, or one, indicatingretention.You can imagine two ways in which such multi-ple, localized rearrangements might happen: a progressiverearrangements model with ongoing inversions, deletions,and duplications involving a localized area, or a cata-strophic model in which the chromosome is shattered intofragments that are stitched back together in random orderby nonhomologous end joining (Figure Q20–2).A. Which of the two models in Figure Q20–2 accountsmore readily for the features of…In Metastatic Breast Cancer [such as in Breast Invasive Ductal Carcinoma; Breast Invasive Carcinoma, NOS; Breast Invasive Cancer, NOS; Invasive Breast Carcinoma; Breast Invasive Lobular Carcinoma; Breast Mixed Ductal and Lobular Carcinoma] what role does the genes Tp53 and Tp63 have? Would one of them affect the other (i.e. mutation, etc) or there is not relationship among the two genes at all.How can I study a protein cancer cells?
- Why Embryonic stem cells research is the most controversial topic in Medical research in this country today?Hi, can you elaborate about these two concepts: 1) Can telomere inhibition be good cancer treatment? 2) Can cancer steam cells hypothesis be a good / bad approach?Skin cancer carries a lifetime risk nearly equal to that of allother cancers combined. Following is a graph [modified fromK. H. Kraemer (1997). Proc. Natl. Acad. Sci. (USA) 94:11–14]depicting the age of onset of skin cancers in patients with orwithout XP, where the cumulative percentage of skin cancer is plotted against age. The non-XP curve is based on 29,757 cancerssurveyed by the National Cancer Institute, and the curverepresenting those with XP is based on 63 skin cancers from theXeroderma Pigmentosum Registry.
- How gene therapy or cell therapy can help cure diseases? What kinds of diseases do gene and cell therapy treat? What is the difference between gene therapy and cell therapy? What are the different approaches to gene and cell therapy? What risks are associated with gene and cell therapy? What are the ethical issues associated with gene and cell therapy? What are stem cells? Why are stem cells so important in gene and cell therapy?Is it correct to say that the palladin gene causes cancer?What are the key findings of cancer genomics studies as they relate to chromatin biology?(300 word limit)
- * Google Translate x + re.com/courses/49703/quizzes/244266/take/questions/5315835 Understanding BAC-23 better might be the difference in curing cancer and saving millions of lives! You must sequence its genome and find the genetic code that makes the cancer curing protein. After running several tests, you have found the correct gene segment to be: GGG UCG ACA CUC UUU. Remember that bacteria are weird and their genes are made from a single strand with ribose sugar backbones! 1. Give the correct DNA template for this bacterial gene segment (GGG UCG ACA CUC UUU). ***Please use the following format or it will be marked incorrect*** Example: ABC DEF GHI JKL MNO, all caps, organized in threes with a space in between. Please make my life easier 2. Using the genetic code provided (GGG UCG ACA CUC UUU), translate this gene segment. ***Please use the following format or it will be marked incorrect*** Example: ABC DEF GHI JKL MNO, all caps, organized in threes with a space in between. Please make…1. Cancer genetics Breast cancers can be divided into several classes. One type of breast cancer, classified as HER2 positive ("HER2+"), represents 15-20% of breast cancers. Most HER2+ cancers arise due to amplification of the HER2 gene (without any mutation of the HER2 protein coding region). HER2 amplification is also associated with several other types of cancer (e.g. stomach cancer). Would the HER2 gene be considered a proto-oncogene or a tumor suppressor gene? Justify your answer based on the function of the HER2 protein (look it up). b. How does amplification of HER2 promote cancer? c. Some HER2+ cancers have become resistant to the antibody drug. These cells were found to have mutations of the PTEN gene (look for information about the PTEN gene). Are these likely to be recessive loss of function mutations or dominant gain of function mutations of PTEN? Justify your answer, relating PTEN mutations to drug resistance.HELP PLEASE NO EXPLANATION NEEDED Which one is correct about somatic mutations? They can be inherited to progeny They can cause cancer They happen during fertilization They cannot be repaired