Which of the following changes goes along with a decreased clearance and no change in volume of distribution? Please select one: a. shorter half-life, higher steady state concentration b. Increased initial concentration after an i.v. bolus, longer time to steady state c. Longer time to steady state, higher steady state concentration d. Longer time to steady state, lower steady state concentration e. longer time to steady state, shorter half-life
Which of the following changes goes along with a decreased clearance and no change in volume of distribution? Please select one: a. shorter half-life, higher steady state concentration b. Increased initial concentration after an i.v. bolus, longer time to steady state c. Longer time to steady state, higher steady state concentration d. Longer time to steady state, lower steady state concentration e. longer time to steady state, shorter half-life
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Which of the following changes goes along with a decreased clearance and no change in volume of distribution? Please select one: a. shorter half-life, higher steady state concentration b. Increased initial concentration after an i.v. bolus, longer time to steady state c. Longer time to steady state, higher steady state concentration d. Longer time to steady state, lower steady state concentration e. longer time to steady state, shorter half-life
Transcribed Image Text:A drug follows linear one compartment pharmacokinetics, ke = 0.14 hr¹ and volume
of distribution 18 L.
• Calculate a suitable i.v. bolus dose to maintain plasma drug concentrations above 6
mg/L for 8 hours. What is the initial plasma concentration? (C)
• What is half life of this drug? (t1/2)
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