Sickle-cell anemia is a recessive autosomal disorderthat is caused by an amino acid substitution in theβ-hemoglobin protein. The DNA mutation underlyingthis substitution is a SNP that alters a GAG codon forthe amino acid glutamate to a GTG that codes a valine.The frequency of sickle-cell anemia among AfricanAmericans is about 1/400. What is the frequency ofthis GTG codon in the β-hemoglobin gene amongAfrican Americans?
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Sickle-cell anemia is a recessive autosomal disorder
that is caused by an amino acid substitution in the
β-hemoglobin protein. The DNA mutation underlying
this substitution is a SNP that alters a GAG codon for
the amino acid glutamate to a GTG that codes a valine.
The frequency of sickle-cell anemia among African
Americans is about 1/400. What is the frequency of
this GTG codon in the β-hemoglobin gene among
African Americans?
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