Questions are either true or false about for the following statements on Notch signaling please help. how do i work throuhg these During R8 determination, cells with higher Notch ligand Dl will induce higher expression of Notch target gene Enhancer of Split complexes [E(spl)] in the neighboring cells and inhibit their differentiation into R8 neurons. In the absence of Notch ligands, Su(H) will bind to the corepressor proteins and repress Notch target gene expression. Therefore the effects of the Notch receptor mutation can be different from that of the Su(H) mutations Notch signaling has multiple functions during eye development, including regulation of cell proliferation, lateral inhibition, selection of the first retinal neuron, and recruitment of cone cells. These different functions are all mediated by Notch signaling targets the Enhancer of Split complexes [E(spl)]. Mutations that specifically block endocytosis of Notch ligand Dl (in the Dl expressing cells) will inhibit Notch signaling activation in the surrounding cells even in the presence of Notch and Dl binding. Expression of the Notch ligand Dl will only activate Notch signaling in the surrounding cells but not in the Dl-expressing cells themselves.

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...

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Questions are either true or false about for the following statements on Notch signaling

please help. how do i work throuhg these

During R8 determination, cells with higher Notch ligand Dl will induce higher expression of Notch target gene Enhancer of Split complexes [E(spl)] in the neighboring cells and inhibit their differentiation into R8 neurons.

In the absence of Notch ligands, Su(H) will bind to the corepressor proteins and repress Notch target gene expression. Therefore the effects of the Notch receptor mutation can be different from that of the Su(H) mutations

Notch signaling has multiple functions during eye development, including regulation of cell proliferation, lateral inhibition, selection of the first retinal neuron, and recruitment of cone cells. These different functions are all mediated by Notch signaling targets the Enhancer of Split complexes [E(spl)].

Mutations that specifically block endocytosis of Notch ligand Dl (in the Dl expressing cells) will inhibit Notch signaling activation in the surrounding cells even in the presence of Notch and Dl binding.

Expression of the Notch ligand Dl will only activate Notch signaling in the surrounding cells but not in the Dl-expressing cells themselves.

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