Mutations in the BRCA genes have been shown to be related to a higher incidence of breast cancer in humans, and genetic tests are available that enable women to discover whether they carry versions of the gene associated with high risk. However, even early detection of breast cancer does not guarantee a cure. What considerations can you think of for and against advising women to take the tests? ·

Mutations in the BRCA genes have been shown to be related to a higher incidence of breast cancer in humans, and genetic tests are available that enable women to discover whether they carry versions of the gene associated with high risk. However, even early detection of breast cancer does not guarantee a cure. What considerations can you think of for and against advising women to take the tests? ·

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter17: Biotechnology And Genomics

Section: Chapter Questions

Problem 3VCQ: Figure 17.15 In 2011, the United States Preventative Services Task Force recommended against using...

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The decision by some high-risk women to have their breasts removed to prevent the possibility of developing cancer could be a truly life-altering decision. At first glance, this decision could make sense for those women who are at elevated risk due to genetic or family history factors. Counter that with living in a society that seems to be moving toward even greater obsession with female breasts at earlier ages (e.g., breast implants for 16th birthdays!) Learn more about oncogenes and breast cancer.: What are the benefits of learning you have a gene that may lead to cancer? What are the disadvantages of receiving such knowledge?
Skin cancer carries a lifetime risk nearly equal to that of allother cancers combined. Following is a graph [modified fromK. H. Kraemer (1997). Proc. Natl. Acad. Sci. (USA) 94:11–14]depicting the age of onset of skin cancers in patients with orwithout XP, where the cumulative percentage of skin cancer is plotted against age. The non-XP curve is based on 29,757 cancerssurveyed by the National Cancer Institute, and the curverepresenting those with XP is based on 63 skin cancers from theXeroderma Pigmentosum Registry.
Genetic tests that detect mutations in the BRCA1 and BRCA2 oncogenes are widely available. These tests reveal a number of mutations in these genes—mutations that have been linked to familial breast cancer. Assume that a young woman in a suspected breast cancer family takes the BRCA1 and BRCA2 genetic tests and receives negative results. That is, she does not test positive for the mutant alleles of BRCA1 or BRCA2. Can she consider herself free of risk for breast cancer?
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