fill in the blank: 1. The expression of a gene, its pre-mRNA can undergo   , resulting in multiple mRNA isoforms encoding variants of protein products. 2. ___________  and                       are two widely used technologies in whole transcriptome profiling, to quantify the                     abundance of RNAs of expressed genes. 3. Whole transcriptome profiling using _____________ does not require prior knowledge of genome sequences. 4. Next generation whole transcriptome arrays (WTAs) contain comprehensive DNA probes allowing detection as well as quantitative measurements of all expressed RNA species, by assessing the p-values at both  _____________    and _____________.

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