Draw the product formed by the condensation of citrulline with aspartate catalyzed by argininosuccinate synthetase in the second step of the urea cycle. Use wedges and dashes to indicate the stereochemistry at asymmetric centers. Provide the structure in the protonation state found in physiological conditions. H₂N HN, O Ⓒ H H3N Drawing COO Q argininosuccinate synthetase ATP -OOC, H3N AMP, PPi COO-

Draw the product formed by the condensation of citrulline with aspartate catalyzed by argininosuccinate synthetase in the second step of the urea cycle. Use wedges and dashes to indicate the stereochemistry at asymmetric centers. Provide the structure in the protonation state found in physiological conditions. H₂N HN, O Ⓒ H H3N Drawing COO Q argininosuccinate synthetase ATP -OOC, H3N AMP, PPi COO-

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter23: Enzymes

Section: Chapter Questions

Problem 23.57P: 7 (Chemical Connections 23C) Which amino acids of the active site interact with the =CH2 group of...

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An enzymatic assay was performed using the enzyme phophofructokinase-1, which catalyses the committed step of the glycolysis pathway. What is the final concentration of the fructose 6-phosphate substrate in a test tube containing the following: 250 µL of 150pM fructose 6-phophate, 100 µL 20 mg.ml-1 phosphofructoskinase-1 and 150 µL 100mM buffer pH 7.5
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One of the steps in the pentose phosphate pathway for glucose catabolism is the reaction of sedoheptulose 7-phosphate with glyceraldehydes 3-phosphate in the presence of a transaldolase to yield erythrose 4-phosphate and fructose 6-phosphate. (a) The first part of the reaction is the formation of a protonated Schiff base of sedoheptulose 7-phosphate with a lysine residue in the enzyme followed by a retro-aldol cleavage to give an enamine plus erythrose 4-phosphate. Show the structure of the enamine and the mechanism by which it is formed. (b) The second part of the reaction is a nucleophilic addition of the enamine to glyceraldehyde 3-phosphate followed by hydrolysis of the Schiff base to give fructose 6-phosphate. Show the mechanism.
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ondition wherein there is cholesterol deposition in the lamina propria of gallbladder
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