As discussed in Lipids 3, SREBPs are a type of transcription factorinvolved in lipid homeostasis. SREBPs regulate the expression of genesthat encode for anabolic enzymes.Normally SREBPs are degraded within 3 hours. Pancreatic cancer cellsprevent this from happening, which increases cholesterol productionwithin the tumor.If maintaining SREBPs for a longer period of time increases lipidsynthesis, then these transcription factors are:O introducing a point mutation within the mRNA, causing the ribosome tosynthesize a better proteinbinding to the promoter and preventing RNA polymerase from accessing thetranscription start siteintroducing a premature stop codon within the mRNA, causing the ribosometo terminate translationbinding upstream of the promoter and recruiting RNA polymerase to thetranscription start sitebinding to the origin of replication and recruiting DNA polymerase forbidirectional synthesis

The full form of SREBPs is Sterol regulatory element binding proteinsSREBPsare composed of two…

Answered: As discussed in Lipids 3, SREBPs are a…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

See similar textbooks

Similar questions

Suppose that you have cancer cell line X was treated with drug Y toincrease the expression levels of protein Z which is a tumorsuppressor gene.Explain How can you study protein Z in these cells? (no need for these qustions)Explain how can you study protein Z components? (needed)
Melanosomes are specialized lysosomes that storepigments for eventual release by exocytosis. Various cellssuch as skin and hair cells then take up the pigment, whichaccounts for their characteristic pigmentation. Mousemutants that have defective melanosomes often have paleor unusual coat colors. One such light-colored mouse, theMocha mouse (Figure Q13–3), has a defect in the gene forone of the subunits of the adaptor protein complex AP3,which is associated with coated vesicles budding from thetrans Golgi network. How might the loss of AP3 cause adefect in melanosomes?
Phorbol esters have been observed to induce the transcription of AP-1–influenced genes. Explain how this processcould occur. What are the consequences of AP-1 transcription? What role does intermittent exposure to phorbol estershave on an individual’s health?
A study is conducted to assess the molecular mechanisms of hormone X. A radioactively labeled form of this hormone is incubated with human cells in tissue culture for 30 minutes, and then incubated briefly with a cross-linking agent. The plasma membrane, cytosolic, and nuclear fractions are isolated from the cell lysate, and the subcellular proteins are separated from these fractions by gel electrophoresis. The only protein bound to the labeled hormone is identified in the new clear fraction. Hormone X is most likely which of the following? Epinephrine Glucagon Growth hormone Insulin Thyroxine
Atherosclerosis can obstruct or block flow in arteries, including those that provide oxygenated blood to the heart. Elevated levels of [ Select ] ["LDL, and VLDL", "HDL"] are associated with atherosclerosis, most likely because of their role in delivery of lipids to peripheral tissues and cells. Smooth muscle cells are recruited to the site of damage, where they [ Select ] ["induce apoptosis of endothelial cells", "proliferate"] , hence expanding the extent of the lesion.
Explain the function(s) of Hsp90. Name two factors which lead to the increase of this protein in cells.
Autophagy is an évolutionary conserved catabolic process devoted to the degradation of intracellular components. Which of the following would you observe during autophagy? Select all that apply MTOR inhibition through phosphorylation and activation of TSC proteins MTOR activation and phosphorylation of downstream target proteins Increased expression of Rab7 which mediates lysosomal fusion Acute inflammatory response
At puberty, the adolescent human body undergoes changes in both structure and function of several organ systems, primarily under the influence of estrogen and testosterone steroid hormones. Which of the following best explains how two molecules can trigger many different types of systemic changes that occur during adolescence? A Estrogen and testosterone are both produced in very large concentrations by nearly ev- ery cell in the body. B с D Estrogen and testosterone bind to specific receptors inside many types of cells, each with different signal transduction pathways. Estrogen and testosterone bind to different membrane-bound receptors on different cells, initiating different transduction pathways. Estrogen and testosterone are able to cross the membrane of some cells but not others.
What characteristic of the plasma membrane allows for themovement of the G protein complex toward and away fromthe receptor protein?
new class of cholesterol-lowering treatments that utilize small interfering RNAs (siRNAs) are currently in clinical trials. These work by binding to and degrading specific mRNAs that encode apolipoproteins (O'Donoghue et al., 2022). Which specific cells do these siRNAs have to be directed to in order to be effective? O adipose cells O hepatocytes macrophages pancreatic beta cells
GLUT4 is a protein channel that facilitates the transport of glucose into the cell. Under nor- mal conditions, some of the GLUT4 proteins that are synthesized by the cell do not become active and are instead stored within the membranes of vesicles. The insulin receptor tyrosine kinase (TRK) is a receptor protein that facilitates the decrease of glucose concentration in the bloodstream by increasing the uptake of glucose by cells. When the insulin hormone binds the insulin TRK receptor, a signal transduction pathway causes the activation and addition of GLUT4 to the cell membrane. A model of this signal transduction pathway is illustrated in the figure below. insulin insulin receptor cytoplasm A model of the insulin TRK receptor signal-transduction pathway. Which of the following best predicts the effect of a loss of function of the insulin TRK2 A B C D The stimulation of the signal transduction pathway will increase. The storage of GLUT4 inside the cell will increase. The concentration…
FIG. 7.3 ESSENTIALS Peptide Hormone Synthesis and Processing (a) Peptide Hormone Synthesis Peptide hormones are made as large, inactive preprohormones that include a signal sequence, one or more copies of the hormone, and additional peptide fragments. 1 Messenger RNA on the ribosomes binds amino acids into a peptide chain called a preprohormone. The chain is directed into the ER lumen by a signal sequence of amino acids. Ribosome 1 mRNA- Endoplasmic reticulum (ER) Preprohormone 2 3 (b) Preprohormones 2 Enzymes in the ER chop off the signal sequence, creating an inactive prohormone. Signal sequence Prohormone Transport vesicle passes from the 3 The prohormone 4 Secretory vesicles containing enzymes and prohormone bud off the Golgi. The enzymes chop the prohormone into one or more active peptides plus additional peptide fragments. PreproTRH (thyrotropin-releasing hormone) has six copies of the 3-amino acid hormone TRH. Preprohormone ER through the Golgi complex. Golgi complex Tim 3 d C 4…

SEE MORE QUESTIONS

Recommended textbooks for you

Biochemistry

ISBN:

9781319114671

Author:

Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:

W. H. Freeman

Lehninger Principles of Biochemistry

Biochemistry

ISBN:

9781464126116

Author:

David L. Nelson, Michael M. Cox

Publisher:

W. H. Freeman

Fundamentals of Biochemistry: Life at the Molecul…

Biochemistry

ISBN:

9781118918401

Author:

Donald Voet, Judith G. Voet, Charlotte W. Pratt

Publisher:

WILEY

Biochemistry

ISBN:

9781319114671

Author:

Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:

W. H. Freeman

Lehninger Principles of Biochemistry

Biochemistry

ISBN:

9781464126116

Author:

David L. Nelson, Michael M. Cox

Publisher:

W. H. Freeman

Fundamentals of Biochemistry: Life at the Molecul…

Biochemistry

ISBN:

9781118918401

Author:

Donald Voet, Judith G. Voet, Charlotte W. Pratt

Publisher:

WILEY

Biochemistry

ISBN:

9781305961135

Author:

Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal

Publisher:

Cengage Learning

Biochemistry

ISBN:

9781305577206

Author:

Reginald H. Garrett, Charles M. Grisham

Publisher:

Cengage Learning

Fundamentals of General, Organic, and Biological …

Biochemistry

ISBN:

9780134015187

Author:

John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson

Publisher:

PEARSON

SEE MORE TEXTBOOKS