a) What is the chromosomal abnormality associated with Fragile-X Syndrome? b) What is the phenotype associated with this disorder? c) How is this trait inherited
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a) What is the chromosomal abnormality associated with Fragile-X Syndrome?
b) What is the
c) How is this trait inherited?
Step by step
Solved in 4 steps
- For an X-linked recessive disease where the father is unaffected: a) An affected father cannot pass the disease mutation on to his daughters. b) all affected mothers will be heterozygous at the trait locus. c) a homozygous affected mother will have only affected male offspring. d) a homozygous affected mother will have only affected female offspring. e) if a homozygous affected mother mates with an unaffected father, 75% (on average) of the male offspring will be affected.Describe both the primary gene or protein defect and the resulting phenotype for the following diseases a) Cystic fibrosis, b) Gaucher's diseasea man has simpson syndrome, an addiction to certain television series. his wife does not have this syndrome. the couple has four children. A) can this syndrome be caused by autosomal recessive gene? B) Can it be caused by an x linked recessive allele ? C) What about wiggly ears?
- Now assume that the pedigree shown in question 1 shows the inheritance of a rare genetic disease. a) The disease is most likely autosomal dominant b) The disease is most likely autosomal recessive c) The disease is equally likely to be either autosomal dominant or autosomal recessive, but cannot be x-linked d) Cannot be determined from the information givenHow is it possible Jonathan has the dominant disorder, Huntington’s Disease, if none of his family had it? a) The mutant allele remained ‘hidden’ in previous generations. b) He is homozygous for mutant huntingtin alleles unlike his grandparents, who are clearly heterozygous for the condition. c) The appearance of Huntington Disease in him might be the result of a new mutation appearing during his lifetime. d) His parents and grandparents were ashamed to admit they had it.What is the genetic basis (karyotypes) and phenotype for each of the following disorders a) Edwards syndrome b) Patau syndrome c)Klinefelter syndrome d) Down syndrome.
- A man and a woman have a child with cystic fibrosis. Neither parent has cystic fibrosis. How could this happen? a) Both parents carry the cystic fibrosis allele, and each passed that allele to their child. b) The child had a spontaneous mutation on both copies of their CFTR alleles, leading to cystic fibrosis. c) One parent gave the child two copies of the cystic fibrosis CFTR allele. c) One parent gave the child a wild type CFTR allele, and the other parent gave them a cystic fibrosis CFTR gene.3a) Name 5 genetic diseases/disorders caused by chromosome mutation, the chromosomes involed and their main symptoms b) Write short notes on the following: i) Autosomal dominant traits ii)Autosomal recessive traits iii)X-linked dominant traits iv)X-linked recessive traits v) Y-linked traitsWhat causes most of the phenotypic abnormalities in someone with Down's Syndrome? A) They have many gene mutations that produce nonfunctional proteins. B) They express too much of some proteins during development. C) Their cells cannot go through mitosis properly during development because they have an odd number of chromosomes. D) Their chromosomes cannot pair during meiosis.
- a) What is the mode of inheritance in the following pedigree for the disease trait (autosomal dominant or recessive?) b) What are the possible genotypes for each individual in the pedigree? (Hint: You can use “A” for dominant allele and “a” for recessive allele)In an X linked condition "b" , a person with genotype XbX , can be described as what ? a) female who has the disease b) female who is a carrier c) male with disease d) male with no disease ( Not sure if that was more detailed ? )PKU is an inherited disease caused by a recessive allele. If a woman and her husband, who are both carriers (heterozygotes) for the disorder, have three children, what is the probability of each of the following? a) All three children are of normal phenotype. b) All three children have the disease. c) Any 2 of the three children have the normal phenotype.