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OH -% OH OH H₂ HO HN, OH Figure 1 Structure of TTX Na-OH₂ on Channel Membrane Jon Chamel Tetrodotoxin Figure 1 Binding of TTX to Sodium channel www.www. www.www www.www. 2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by binding to the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signal transmission. Propose a computational research project in which you would use TTX as a starting material to design a painkiller (an analgesic drug). Note the following: (50 Marks) You must clearly mention the computational methods/techniques and their significance in this research. Sodium channel Nv1.7 is a transmembrane protein. • TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. This is schematically represented in Figure 2. Strong Painkillers partially/ irreversibly block Na channels.

OH -% OH OH H₂ HO HN, OH Figure 1 Structure of TTX Na-OH₂ on Channel Membrane Jon Chamel Tetrodotoxin Figure 1 Binding of TTX to Sodium channel www.www. www.www www.www. 2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by binding to the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signal transmission. Propose a computational research project in which you would use TTX as a starting material to design a painkiller (an analgesic drug). Note the following: (50 Marks) You must clearly mention the computational methods/techniques and their significance in this research. Sodium channel Nv1.7 is a transmembrane protein. • TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. This is schematically represented in Figure 2. Strong Painkillers partially/ irreversibly block Na channels.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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OH -% OH OH H₂ HO HN, OH Figure 1 Structure of TTX Na-OH₂ on Channel Membrane Jon Chamel Tetrodotoxin Figure 1 Binding of TTX to Sodium channel www.www. www.www www.www.
Transcribed Image Text:OH -% OH OH H₂ HO HN, OH Figure 1 Structure of TTX Na-OH₂ on Channel Membrane Jon Chamel Tetrodotoxin Figure 1 Binding of TTX to Sodium channel www.www. www.www www.www.
2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by binding to the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signal transmission. Propose a computational research project in which you would use TTX as a starting material to design a painkiller (an analgesic drug). Note the following: (50 Marks) You must clearly mention the computational methods/techniques and their significance in this research. Sodium channel Nv1.7 is a transmembrane protein. • TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. This is schematically represented in Figure 2. Strong Painkillers partially/ irreversibly block Na channels.
Transcribed Image Text:2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by binding to the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signal transmission. Propose a computational research project in which you would use TTX as a starting material to design a painkiller (an analgesic drug). Note the following: (50 Marks) You must clearly mention the computational methods/techniques and their significance in this research. Sodium channel Nv1.7 is a transmembrane protein. • TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. This is schematically represented in Figure 2. Strong Painkillers partially/ irreversibly block Na channels.
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