1. Propose a synthesis for the following transformation. Show the intermediate compound that is produced after each reagent. Remember: A good synthesis will produce the desired regioisomer as the major product. Br3C. O₂N Br

1. Propose a synthesis for the following transformation. Show the intermediate compound that is produced after each reagent. Remember: A good synthesis will produce the desired regioisomer as the major product. Br3C. O₂N Br

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter8: Haloalkanes, Halogenation, And Radical Reactions

Section: Chapter Questions

Problem 8.28P

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Concept explainers

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.

Question

Nitesh

1. Propose a synthesis for the following transformation. Show the intermediate compound
that is produced after each reagent. Remember: A good synthesis will produce the desired
regioisomer as the major product.
Br3C.
O₂N
Br

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